SS-31, also known as Elamipretide, is a mitochondria-targeted tetrapeptide. Its mechanism of action primarily involves the mitigation of mitochondrial dysfunction, a common factor in many degenerative diseases and age-related conditions.
The peptide selectively targets cardiolipin, an essential phospholipid in the inner mitochondrial membrane, preserving its function and structure. By preventing the formation of reactive oxygen species (ROS), it mitigates oxidative stress and cellular damage. Research suggests SS-31’s diverse benefits extend across heart disease, neurodegenerative disorders, kidney disease, and aging, improving mitochondrial function.
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[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4921212/
[2] https://pubmed.ncbi.nlm.nih.gov/34302976/
[3] https://pubmed.ncbi.nlm.nih.gov/29589186/
[4] https://www.auajournals.org/ doi/full/10.1016/j.juro.2017.02.3115
[5] https://pubmed.ncbi.nlm.nih.gov/26719366/
[6] https://pubmed.ncbi.nlm.nih.gov/17151329/
[7] https://pubmed.ncbi.nlm.nih.gov/30381054/
[8] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC5847870/
[9] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC2584902/
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