Synthetic peptide PT-141, also known as Bremelanotide, is primarily utilized in the treatment of sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). This peptide is a melanocortin receptor agonist, specifically binding to the MC3 and MC4 receptors, which are known to regulate sexual behavior.
The mechanism of PT-141’s action is unique when compared to other erectile dysfunction or sexual arousal medications. Instead of acting on the vascular system like Viagra, PT-141 operates directly on the nervous system by increasing the level of dopamine—a neurotransmitter that plays a key role in the regulation of sexual behavior. It’s this distinctive mode of action that allows PT-141 to be effective in treating sexual disorders related to psychological and physical issues.
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[1] https://www.sciencedirect.com/science/ article/abs/pii/S0196978105004602
[2] https://academic.oup.com/jsm/ article-abstract/3/4/628/6882956
[3] https://www.fda.gov/news-events/ press-announcements/ fda approves new treatment hypoactive sexual desire disorder premenopausal women
[4] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC8788464/
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