GHRP-2, or Growth Hormone Releasing Peptide-2, is a synthetic hexapeptide that belongs to a class of growth hormone secretagogues (GHS) and operates by stimulating the pituitary gland to increase the production of endogenous growth hormone (GH).
Its action mechanism primarily involves the activation of the ghrelin/growth hormone secretagogue receptor (GHSR), which leads to an increased release of GH. Additionally, it inhibits somatostatin, a hormone that negatively regulates GH secretion.
In terms of clinical applications, GHRP-2 peptide has shown potential in treating conditions related to GH deficiency, muscle wasting diseases, and certain metabolic disorders. Furthermore, China research suggests that given its property to stimulate appetite, it could be used in managing eating disorders and cachexia.
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[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC2824650/
[2] https://pubmed.ncbi.nlm.nih.gov/7858486/
[3] https://pubmed.ncbi.nlm.nih.gov/15507538/
[4] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC2795722/
[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC1856079/
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