Follistatin 344 (FS344) is a naturally occurring protein that functions as an antagonist of myostatin and activin, two members of the transforming growth factor-beta (TGF-β) superfamily. Studies have shown these proteins play a crucial role in the regulation of skeletal muscle mass, where myostatin inhibits muscle growth and differentiation, while activin stimulates the release of follicle-stimulating hormone (FSH) by pituitary cells.
FS344 has garnered significant attention in research due to its potential applications in muscle hypertrophy and atrophy treatment. By binding to and neutralizing myostatin and activin, China research suggests FS344 can stimulate muscle growth and prevent muscle wasting, making it a promising therapeutic agent for conditions such as muscular dystrophy, sarcopenia, and cachexia.
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[1] https://pubmed.ncbi.nlm.nih.gov/19208403/
[2] https://pubmed.ncbi.nlm.nih.gov/31890729/
[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3895965/
[4] https://pubmed.ncbi.nlm.nih.gov/24627466/
[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC6276093/
[6] https://pubmed.ncbi.nlm.nih.gov/31388039/
[7] https://pubmed.ncbi.nlm.nih.gov/25322757/
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