Human C peptide, a short 31-amino acid polypeptide, is synthesized as a byproduct during the production of insulin in the pancreatic β-cells. The release ratio of insulin to C-peptide is almost 1:1 making it an important clinical marker for evaluating endogenous insulin secretion, particularly in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM).
Human C peptide has shown promise in the treatment of diabetic complications. A series of clinical trials have suggested that C-peptide replacement therapy might be beneficial in patients with T1DM, improving renal function, nerve conduction, and microvascular blood flow.
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[1] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC10512826/
[2] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC8000702/
[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC4317306/
[4] https://diabetesjournals.org/care/ article/35/3/465/28711/ Persistence of Prolonged C peptide Production in
[5] https://diabetesjournals.org/care/ article/44/2/390/35493/ Clinical Impact of Residual C-Peptide Secretion in
[6] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC9543865/
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