Kisspeptin, a peptide hormone, plays a crucial role in reproductive health. It is encoded by the KISS1 gene and primarily produced in the hypothalamus. Kisspeptin acts as a potent stimulator of GnRH (Gonadotropin-Releasing Hormone), which in turn causes the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. These hormones regulate sexual maturity and function in both males and females.
The primary therapeutic potential of kisspeptin lies in its ability to modulate the hypothalamic-pituitary-gonadal axis. It can be used to treat disorders related to puberty, fertility, and menstruation. For instance, it has been studied for its potential to trigger ovulation in women undergoing in vitro fertilization (IVF).
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[1] https://pubmed.ncbi.nlm.nih.gov/27340201/
[2] https://pubmed.ncbi.nlm.nih.gov/26277870/
[3] https://www.sciencedirect.com/science/ article/abs/pii/S1471489222001461
[4] https://pubmed.ncbi.nlm.nih.gov/23019497/
[5] https://onlinelibrary.wiley.com/ doi/abs/10.1111/jne.13081
[6] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC8388553/
[7] https://pubmed.ncbi.nlm.nih.gov/31075715/
[8] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC7711897/
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